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Generation of novel long-acting GLP-1R agonists using DARPins as a scaffold

To enhance the targeting of HCC tissue and reduce the systemic toxicity of cheotmherapy drugs, we found that SP94 (SFSIIHTPILPL), a novel peptide identified by Lo et al

Link between GIP and osteopontin in adipose tissue and insulin resistance

Patients with non-alcoholic steatohepatitis (NASH) or non-alcoholic fatty liver disease (NAFLD) with concurrent diabetes or obesity might benefit from the hepatic anti-inflammatory effects observed in clinical studies, though GLP-1 receptor agonists are not yet FDA-approved specifically for liver disease

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