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Fibroblast Growth Factor 21 Improves Whole-Body Metabolic Health In contrast to many candidates being clinically tested as potential NASH therapeutics, FGF21 not only exerts direct effects on the liver to improve its metabolic state, but also acts on whole body metabolism to lighten the metabolic load on the liver

This approach would offer a more comprehensive perspective, using a whole-organism system to substantiate ZNTs efficacy in a more complex biological environment characterized by multicellular interactions

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doi: 10.1007/s40262-018-0728-4 103 OvergaardRVHertzCLIngwersenSHNavarriaADruckerDJ