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Various factors are involved in the progression of DN, such as disorder of oxygen metabolism and lipid metabolism, hyperglycemia, advanced glycosylation products, and inflammatory response [140, 141]

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Thus, we could not confirm any clear G4 structure-dependence for the ING2 5 UTR, raising the possibility that G4 formation is too weak to be detected by conventional G4 detection assays, or that these small molecules bind to non-G4 structures

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