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Fundam Clin Pharmacol (2018) 32(2):17480

Patients with chronic diabetes are more likely to suffer cognitive impairment, and a number of neurodegenerative disorders, including Alzheimers Disease (AD), Parkinsons Disease and other forms of dementia

This pharmacodynamic effect may result in: Apparent reduction in ADHD medication benefit , with patients noticing poorer concentration or increased inattention this reflects sedation masking the stimulant's effects rather than true pharmacological antagonism Unpredictable drowsiness , particularly in children or those sensitive to CNS-active agents Cognitive blunting , which may be mistaken for a worsening of ADHD symptoms There is no clinically significant interaction listed in UK SmPCs or the BNF between stimulant ADHD medications and second-generation antihistamines such as cetirizine, loratadine, or fexofenadine

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The study is interesting as a computer science paper, but the methods and findings dont stand up to medical scientific scrutiny, says Yuval Pinto, MD, an obesity and family medicine doctor at Johns Hopkins Medicine in Baltimore

In such cases, testosterone replacement therapy (TRT) can help