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Most of the studies have been done on rats, and its not clear if the benefits apply to humans
References Gold MS
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2009;89(2):693S-S696
presented a heterozygous CHAC1 deletion mouse model that was protected from kidney disease progression across three different disease models, without any known phenotypic changes under control conditions ( Despite its injury-promoting effects in some organs, CHAC1 contributes to tissue repair in certain contexts
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