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albicans and can catalyze the synthesis of cAMP (Zeng et al., 2022)

Casein kinase 2 (CK2) is an antiapoptotic kinase that maintains cell survival

This is generally temporary and resolves as weight stabilizes, but should be discussed with a healthcare provider if it persists beyond a few months

Several additional isolated case reports have been published detailing tumorous melanosis in association with other immunotherapies, including ipilimumab,7 pembrolizumab,8 9 and dabrafenib/trametinib.10 A single case series consisting of 10 patients with tumorous melanosis was also recently published, though none were treated with T-VEC.11 Here we report our experience with six cases of tumorous melanosis following successful T-VEC therapy, in which follow-up biopsies suggest that complete pathological response in a majority of cases occurs significantly sooner than clinically apparent response