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Secondary Outcome: Secondary Outcomes: Changes in waist circumference, body fat, body lean mass, and metabolic risk factors including levels of plasma glucose, insulin sensitivity, serum lipids, and blood pressure Statistical Analysis Full details previously published 2 and can also be found in the STEP group statistical analysis plan at NEJM.org Statistical analysis approach sought strong control for type I error All endpoints addressing intervention efficacy were analyzed using intention-to-treat approach All endpoints addressing intervention safety were analyzed using per-protocol approach Efficacy endpoints analyzed using 2 estimands Treatment Policy Estimand: intention to treat analysis
Maintenance Phase: Upon reaching target weight goals, a healthcare provider may suggest a lower maintenance dose to sustain outcomes
Do not self-combine: Using retatrutide and semaglutide together is not a routine evidence-based approach
Did you know that semaglutide can significantly reduce body weight and body mass index (BMI) more effectively than a placebo
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Physicians India 62, 6466
