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PLC pathway increases intracellular calcium affecting various cellular processes

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Hepatocellular edema and inflammatory cell infiltration were observed with increased hepatic IL-1 and TNF- mRNA following exposure to 5 m PS particles (20 mg/kg/day body weight) in drinking water for 30 days [69]

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Peroxisome proliferator-activated receptor-gamma ligands induce heme oxygenase-1 in lung fibroblasts by a PPARgamma-independent, glutathione-dependent mechanism