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Preclinical models highlight its role in accelerating recovery from musculoskeletal injuries, making it a promising therapeutic for soft tissue repair and regeneration (3)
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Interestingly, we transfected 293T cells with Myc-labeled ubiquitin, HA-labeled KEAP1, and Flag-labeled NRF2 plasmids and observed that the upregulation of KEAP1 promoted the poly-ubiquitination of NRF2, and SP could down-regulate the KEAP1 expression and block the NRF2 ubiquitination dose-dependently (Supplementary Fig
Nevertheless, these studies collectively suggest potential benefits of lipoic acid for chemotherapy-induced neuropathy at daily doses ranging from 600 mg to 1,800 mg, though the larger trial underscores the need for well-designed regimens and careful patient adherence to confirm efficacy over extended treatment courses
& Cao, T
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