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The metabolism of many chemotherapeutic and endocrine medications is facilitated by cytochrome P450 (CYP) enzymes such CYP3A4, CYP2D6, and CYP2C9, which provide a significant obstacle due to drug-drug interactions (202)

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Some clinicians prescribe semaglutide off-label as part of a weight-loss program

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It's important to note that off-label use is legal and sometimes necessary in medical practice, allowing doctors to adapt treatments to individual patient needs

Glutathione reductase in leaves of cowpea: cloning of two cDNAs, expression and enzymatic activity under progressive drought stress, desiccation and abscisic acid treatment