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Many individual participants in the SURMOUNT trials lost significantly more than the averages suggest
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NLRP3 inflammasome activation induced by hyperglycemia can cause endothelial dysfunction in T2DM
Some of the pharmacoepidemiology data suggested that even lower doses for example, using semaglutide for diabetes without going up to the obesity dose may be just as effective as a higher dose in reducing the incidence of alcohol use disorder
However, the right dosage is key to balancing effectiveness and minimizing side effects
