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After demonstrating its effect in animal studies, such as its effect to improve glucose tolerance after gastric glucose administration in mice (51), a 4 week clinical study was undertaken in drug-nave patients with type 2 diabetes (52)

Its easy to become fixated on the very small and still-debated risk of a medication while ignoring the much larger and clear risks of foregoing treatment

But we have a relatively good idea why weight loss can lead to muscle loss

24.2% mean body weight loss (approximately 58 pounds) at 48 weeks with a 12 mg dose, with 83% of participants losing 15% of body weight and 26% achieving 30% weight loss

The prescription is the last step, not the first

Questi sintomi si manifestano in genere nelle prime settimane di trattamento e tendono a diminuire nel tempo