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Post- L-GSH supplementation, we found increased levels of IFN- in PBMCs ( Figure 5A ), increased levels of TNF- in plasma ( Figure 5C ) and PBMCs ( Figure 5D ), and increased levels of IL-2 in plasma ( Figure 5E ) and PBMCs ( Figure 5F ) when compared to before L-GSH supplementation

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Notably, the G322V mutation of TRIM37, which disrupts the TRIM37TRIM28 interaction, abolished TRIM28 ubiquitination by TRIM37 (Supplementary information, Fig

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In conclusion, our study demonstrates that long-term HFD consumption results in a concomitant increase in hepatic GSSG, protein S -glutathionylation, and TNF levels