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Uncommon and rare adverse effects include cystitis, folliculitis, gastrointestinal infections, hypersensitivity reactions, changes in appetite, depression, insomnia, balance disorders, lethargy, restless leg syndrome, syncope, photophobia, presbyopia, tinnitus, confusion, palpitations, hypertension, hypercholesterolaemia, and weight gain

& Rcker, G

10.1016/S0140-6736(10)60590-9 45

So when a meta-analysis finds GLP-1 patients losing 3035% of total weight as lean mass, the question isn't whether GLP-1s are uniquely catabolic

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Plant and fungal calmodulin: Ca2+-dependent regulation of plant NAD kinase