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GLP-1 receptor agonists are glucose-dependent, meaning they enhance insulin secretion only when blood sugar is elevated

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In ob/ob mice and Zucker rat models, it has consistently reduced fat mass, decreased epididymal and brown adipose tissue weight, and improved lipid profiles without affecting lean tissue or glucose homeostasis

The solution was centrifuged at 1,000 g for 5 min, and the absorbance of the supernatant was measured at 280 nm to determine the lignin content

This ensures precise delivery in preclinical studies and avoids variability in results