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This was achieved by first synthesizing an amphiphilic polymer, polycaprolactone-epsilon-poly(L-lysine) (PCL--PLL), which was co-assembled with polycaprolactone-poly(ethylene glycol) (PCL-PEG) into NPs
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This can impact plaque buildup in arteries
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The activation occurs via trans -phosphorylation of two catalytic tyrosines (Y1234 and Y1235) located in the kinase domain, followed by the subsequent auto-phosphorylation of the two docking tyrosines (Y1349 and Y1356) in the C-terminal tail
IL-4 and IL-13 suppress the production of filaggrin, a structural protein critical for maintaining the stratum corneum
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