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The SURPASS clinical trial program, which evaluated tirzepatide for type 2 diabetes over periods extending to 52 weeks and beyond, demonstrated sustained glycemic improvements without evidence of significant tachyphylaxis (rapid tolerance development) for the primary glucose-lowering effects

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These benefits can further motivate patients to continue with their treatment plan and engage in other components of it, leading to sustained weight loss and overall health improvements

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Namgaladze, D., Fuhrmann, D