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It should be refrigerated at 2C to 8C (36F to 46F), protected from light, and must not be frozen to prevent degradation of the active ingredient
Some facilities use both approaches together for difficult wounds, though research on combined protocols is limited
Archived from the original on 26 April 2015
A study from The Netherlands (Riphagen, 2020) found that after 8.5 years of follow-up of an older cohort (median baseline age=65), a doubling of baseline MMA levels was associated with an increased risk of mortality (HR 11.48, CI 3.3239.64)
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[63] There are not enough studies on whether pills are as effective in improving or eliminating symptoms as intramuscular injections
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