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507 Irisin is a myokine secreted by skeletal muscle

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DISCLOSURES Cindy Wassef, Radhika Shah, Mahin Alamgir, Samantha Ouellette, and Giulia Frias have no conflicts of interest to disclose

Due to distinct tissue expression of receptors, MT-2 is incorporated alongside selective antagonists, genetic models, or specific interventions to attribute observed effects to receptor subtypes

There are over 20 identified gut peptides within the GI tract, many of which play a key role in energy and glucose homeostasis, with the following sections focusing on the incretin hormones GLP-1 and glucose-dependent insulinotropic polypeptide (GIP), CCK, and several others