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Although UPS and autophagy are essential mechanisms for protein degradation, the size of the degraded materials strongly influences the degradation pathway employed (Figure 2A, which are activated by the enzymes E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3 (ubiquitin-protein ligase), are used in covalent bonding to the target protein for alterations during the catalytic cascade (Tonnus et al., 2021)

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