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While more expensive than monotherapy, the 50% additional weight loss over semaglutide alone (15-25% vs 10-15%) justifies the investment for those seeking maximum medical weight loss without surgery

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Similarly, in a cross-sectional study by Johnson et al., analysis of 3-day food records in individuals using GLP-1 RA for at least one month showed that 75% of participants reported having increased their protein intake after treatment, yet only 43% achieved the recommended intake of 1.2 g/kg/day

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doi: 10.1002/14651858.CD004655.pub3