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TH is the rate-limiting enzyme for catecholamine synthesis, leading to dopamine and NE production, and because the ARH lacks the NE-converting enzyme dopamine-hydroxylase, the TH-positive cells in this region are believed to be of a dopaminergic nature

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Generally, the best candidates are women under the age of 60 or within 10 years of menopause onset who have bothersome symptoms, and don't have contraindications to systemic hormone therapy (which include a history of blood clots and certain types of cancer, like breast cancer), according to Faubion