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While MPNST remains a challenging malignancy, several promising advances are underway: MEK Inhibitors in NF1-Associated MPNST Given the dysregulation of the RAS/RAF/MEK pathway in NF1-related tumors, MEK inhibitors like selumetinib have shown efficacy in benign plexiform neurofibromas

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It has low lipophilicity and high protein binding affinity [35]

Dissociation between CSD-evoked metabolic perturbations and meningeal afferent activation and sensitization: implications for mechanisms of migraine headache onset

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