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(Chapter reference, Pickart laboratory data cited therein.) Lipinski CA, Lombardo F, Dominy BW, Feeney PJ

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This gut-lung interorgan communication mechanism demonstrates significant clinical relevance in chronic respiratory diseases, with large-scale cohort studies establishing a strong inverse correlation between gut microbiota -diversity reduction and key clinical parameters including asthma exacerbation frequency and annual lung function decline in COPD (Tangedal et al., 2024)

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