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Comparative work alongside native GLP-1 and tirzepatide enables receptor-selectivity and biased-agonism characterization
The magnitude of this moment is hard to overestimate
23 April 2025 A Correction to this paper has been published: Abbreviations BBB: Bloodbrain barrier CNS: Central Nervous System GFAP: Glial fibrillary acidic protein GLP-1R: Glucagon-like peptide-1 receptor HFD: Highfat diet IB4: Biotinylated isolectin B4 Iba-1: Ionized calciumbinding adaptor molecule-1 ND: Normolipid diet NVU: Neurovascular unit SAL: Saline solution SEMA: Semaglutide References Grundy SM, Brewer HB, Cleeman JI, Smith SC, Lenfant C
By the end, youll understand what GLP-1 is, how it works, who it helps most, and what results to expect
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