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The tripeptide has a donor-atom arrangement that binds copper(II) with high affinity under physiological conditions, and once that was appreciated it became clear that most of the reported activity tracked the complex rather than the free ligand

Choi, H.S

Ferhatbegovic L, Mrsic D, Macic-Dzankovic A

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Another circadian clock protein PER2 inhibits the expression of PAI-1 in a CLOCK/BMAL1-dependent manner as an important factor in the development of these metabolic diseases after the circadian clock system is dysregulated (Oishi et al., 2009)