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Kidney Protection and Brain Health A trial found semaglutide reduced kidney events by 24% in people with type 2 diabetes and chronic kidney disease using a lower dose, not the maximum. GLP-1s also strengthen the blood-brain barrier and enhance neuron survival, with early data hinting at benefits for cognitive decline and Alzheimer's disease. Systemic Anti-Inflammatory Effects GLP-1s reduce systemic inflammation throughout the body. This benefit doesn't get talked about much, though inflammation drives almost every chronic disease
Be cautious if youre under 25 unless theres a specific clinical reason
19 A separate meta-analysis of 4 major clinical trials suggested prolonged use of GLP-1RA was associated with an elevated risk of rapidly worsening DR
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