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doi: 10.1074/jbc.M117.814392 74 IngoldIBerndtCSchmittSDollSPoschmannGBudayKet al

Recent availability of whole genome sequences of numerous insect species, accompanied by RNA interference, X-ray crystallography, enzyme kinetics and site-directed mutagenesis techniques have significantly enhanced our understanding of functional and structural diversity of insect GSTs

Inducers of NRF2, such as SF, interact with specific cysteine residues of KEAP1 leading to dissociation or degradation of the Cul3KEAP1 complex and stabilization of NRF2, which translocates to the nucleus activating ARE-dependent genes (Zhang et al., 2004

It is also a reserve supply for cysteine, which plays an important role in protein synthesis

doi: 10.24095/hpcdp.36.9.03 62 RitchieI

Pregnant and lactating women: Consult your doctor before use to avoid adverse effects on both mother and baby