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doi:10.1007/8904_2016_531

Notably, after a 4-week washout period these beneficial effects diminished, with the exception of clinical severity scores

Traditionally its been assumed that there are two essential fatty acids, and those are linoleic acid and alpha-linolenic acid, but recent research suggests that the long-chain DHA and AA, arachidonic acid, and not ALA and LA, may be essential

Future research should focus on surface modification strategies (such as polydopamine coating) to regulate ion release kinetics or develop multifunctional systems with clear metabolic pathways to balance efficacy and safety

408 Additionally, studies of other PD-1 inhibitors combined with chemotherapy have provided further support for this strategy

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