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Preclinical fat-loss evidence Ng et al
The folate-cobalamin interaction is pivotal for normal synthesis of purines and pyrimidines and the transfer of the methyl group to cobalamin is essential for the adequate supply of tetrahydrofolate, the substrate for metabolic steps that require folate
It also found no nonclinical toxicity studies sufficient to inform safety and concluded that nonclinical pharmacological evidence was lacking to support wound-healing effectiveness
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Medications in this category include: Metformin, H2 blockers and PPI (proton pump inhibitors) used to block acid production in the GI tract
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