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The Pyo et al

Melanie Jay, M.D., professor of medicine and population health at the NYU Grossman School of Medicine

Altogether, these findings suggest that certain -KG competitors including DM-succinate and ITA recapitulate -KG insufficiency to inhibit the YBX1AMPK axis in human cells, reinforcing the importance of -KG as an epigenetic cofactor for energy sensing

Further phase 2 and 3 studies are ongoing to confirm its long-term efficacy and safety in obesity and T2D

By the end of this post, we aim to provide a comprehensive understanding of how these two approaches can interact and what precautions should be taken