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Gupta D, Jetton TL, Mortensen RM, Duan SZ, Peshavaria M, Leahy JL

"Semaglutide versus placebo in people with obesity-related heart failure with preserved ejection fraction: a pooled analysis of the STEP-HFpEF and STEP-HFpEF DM randomised trials"

Safe Titration and Monitoring: Both medications require a gradual increase in dosage (titration) over several weeks or months to minimize common, temporary side effects like nausea, vomiting, and digestive issues

While medication is a vital tool for many, the foundation of metabolic health will always be Lifestyle Medicine

Discontinuation should be reserved for cases where heart rate changes are clearly problematic and alternative therapies are available

However, people adapted to using ketones instead of glucose as fuel have suffered no ill effects of blood glucose as low as 10 mg/dl