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Notably, a dose of 60mcg/kg resulted in an approximate 150% rise in mean GH levels, while a single dose of 250mcg/kg resulted in a 300% increase in 24-hour mean GH

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"These drugs are thought to work by engaging part of the brain called the hypothalamus, which helps regulate a wide variety of hormones," says Jena Shaw Tronieri, Senior Research Investigator at Penn's Center for Weight and Eating Disorders and a co-author of the study

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P450 enzymes are involved in the conversion of methionine to SAMe, which is a critical component of the methylation pathway

Tirzepatide acts on two pathways (GLP1 and GIP), while semaglutide targets GLP1