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Furthermore, patients with advanced PD may have limited remaining capacity to further slow their neurodegeneration and motor progression, potentially underestimating the true benefit of a disease-modifying intervention
Ongoing research is probing novel applications of GLP-1 agonists beyond diabetes and obesity from potential use in metabolic dysfunction-associated steatohepatitis (MASH) to trials investigating neuroprotective effects in conditions like Parkinsons and Alzheimers disease, though the 2025 phase 3 trials in both conditions failed to show clinical benefit ( [24] ) ( [25] )
& Melton, L
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