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This process is delicate
Importantly, Hinton and colleagues showed that human IgG2 variants harboring Fc fragments with amino acid substitutions that increase their binding affinity towards human FcRn at specifically pH 6.0, but not pH 7.4, had prolonged plasma half-lives in non-human primates (NHPs) [104]
"Safety and Tolerability of the Hexadecapeptide AOD9604 in Humans"
Hoffer ME, Balaban C, Slade MD, Tsao JW, Hoffer B
The cGAS-STING pathway: post-translational modifications and functional implications in diseases
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