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Archived (PDF) from the original on 20 January 2022

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Compared with native GLP-1 which has a half-life of only a couple of minutes because the enzyme DPP-4 rapidly inactivates it semaglutide carries an Aib substitution at position 8 that resists DPP-4 cleavage, plus a C18 fatty-diacid side chain that binds albumin and extends its half-life to about a week

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Important context: this is early data and should be interpreted cautiously