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second, as a substrate for the production of hydrogen sulphide (H 2 S), which feeds the mitochondrial electron transfer chain and mediates per-sulphidation of ATPase and glycolytic enzymes, thereby stimulating cellular bioenergetics

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Liu et al., 2022

By now, olaparib and talazoparib have received FDA and European Medicines Agency approval for the treatment of patients with germline BRCA -mutated HER2 metastatic breast cancer based on the results of the phase 3 OlympiAD and EMBRACA trials, respectively

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