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This shows that care must be taken in interpreting blood measurements, and that ideally one would like to conduct experiments in which both intracellular and extracellular concentrations are measured

Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles

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Notably, the C-terminal FAP cleavage site remains unmodified, suggesting that LY2405319 is likely susceptible to cleavage and inactivation in human serum via loss affinity for KLB ( Figure 3A )

In addition, the cytoprotection was independent of the antioxidant status of the catalase and glutathione peroxidase enzymes, suggesting a direct interaction between creatine and oxidant and/or free radicals