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Men with infertility often exhibit higher levels of mitochondrial ROS and lower levels of mitochondrial membrane potential, which correlates with poor sperm motility and reduced fertilization rates

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The catalytic tetrad formed by Sec, glutamine, tryptophan and asparagine is essential for GPx activity, since these residues are crucial for enzyme-substrate interaction and stabilization of the GSH-GPx interaction [47, 65, 66]