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Nrf2 activator bardoxolone methyl is known to have renoprotective effects (Zhou et al., 2016) and retinal pigment epithelial cells ( NF-B plays a central role in the inflammatory pathway in the development of DKD (Zhou et al., 2014)

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(4) mass-transfer limitations between enzymes and substrates (Luckarift et al., 2004

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doi:10.2174/1573403X18666220411113112 NIH

Given our early stage of development, it may be several years, if at all, before we have demonstrated the safety and efficacy of a product candidate sufficient to warrant approval for commercialization