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Despite the low inhibitory potency of these inhibitors, also compounds from this class have been studied in the clinic

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Obesity (Silver Spring, Md.), 10.1002/oby.24331

Co-localisation and secretion of glucagon-like peptide 1 and peptide YY from primary cultured human L cells

Further, because the functional cells of the pancreas (both exocrine acini and endocrine islets) are highly secretory, FGF21 plays a protective role by enhancing the response to ER stress via activation of the UPR (189, 259)