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The predominant role of PYY is thought to be the maintenance of energy intake, as it is a salient signal of satiety, although some studies have suggested a role for PYY in glucose homeostasis and insulin sensitivity 200,201,202

The treatment responses were short-lived due to the reactivation of the MAPK pathway and/or other mutations (36, 142144)

Weight changes were modest, typically between a 2 to 6 pound loss over six months

However, much of the available evidence comes from laboratory and animal studies, and human clinical research remains limited

coli with very similar yields and purities (Supplementary Fig