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Zepbound is FDA-approved to: Reduce excess body weight and maintain weight reduction long term in adults with obesity or who are overweight with weight-related medical problems Treat moderate to severe obstructive sleep apnea (OSA) in adults with obesity

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For example, a medication used solely for weight management may follow one certification pathway, while the same medication used to treat diabetes or obstructive sleep apnea may require additional review or Special Issuance Authorization

In women with PCOS women, reduced tissue availability or altered metabolism of inositol and/or inositol-derived mediators contributes to elevated insulin resistance

Semaglutide mainly targets the GLP-1 receptor , while retatrutide is a triple agonist that targets GLP-1, GIP, and glucagon receptors