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This can also cause the activation of B cells and differentiation into plasma cells, producing large quantities of antibodies against mSOD1 and other misfolded proteins that would deposit in tissues causing further damage

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Serum nitrite detection Nitrite (NO 2 ), a stable and nonvolatile breakdown product of NO, was measured in sera samples using a Griess Reagent System (Promega, Madison, WI) as described previously [33, 45] and per the manufacturers instructions

This decline can have profound effects on our overall health and well-being