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These conditions can lead to insulin resistance, which makes it more difficult for people who have type 1 diabetes to control their blood sugar

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High mobility group box 1 (HMGB1) secreted by platelets activate the neutrophil receptors such as Toll like receptor-4 (TLR4) and receptor for advanced glycation end products (RAGE) to initiate the neutrophil extracellular trap formation

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This creates both benefits and possible complications

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