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Agents such as oral semaglutide, orforglipron, CagriSema, retatrutide and maridebart cafraglutide have achieved unprecedented mean weight reductions, often exceeding 15% to 20% of baseline body weight in clinical trials.37 Clinicians must keep in mind that pharmacotherapy alone is not a cure for obesity

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Diet Coke was marketed as a great-tasting soft drink that happens to have one calorie, rather than as a diet drink that tastes great, according to the Coca-Cola website

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A 52-week phase 2 trial on AMG133 in people with overweight and obesity is ongoing (NCT05669599)