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While these medications are highly effective, GLP-1 side effectsespecially gastrointestinal issuescan lead to early discontinuation if not properly addressed

Overall, therefore, the main effects of GLP-1 are a reduction of fasting and postprandial blood glucose levels, lowering of body weight and protection from CVD, which are all therapeutic targets in type 2 diabetes (Fig

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SIRT2, present both in nuclear and cytoplasmic compartments, can increase MFN2 and decrease DRP1, thus promoting mitochondrial fusion 104,105