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If there is any doubt about the integrity of a solution whether due to appearance, storage history, or uncertainty about the beyond-use date the safest course of action is always to discard it and seek advice from the trial team, supervising clinician, or a registered pharmacist before proceeding

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The usual daily recommended amounts of methylcobalamin, vitamin B12 either through dietary intake or supplementation should be taken during pregnancy

Place the vial toward the back of the refrigerator, not in the door

10.1093/nar/gkq399 Nucleic Acids Res