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In order for class III peroxidases to produce ROS, two conditions must be satisfied: 1) ion fluxes that lead to extracellular alkalization and 2) an abundant and recyclable oxidant as electron acceptor 37

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For instance, trastuzumab (a monoclonal antibody) is designed to target the HER2 receptor in the case of HER2-positive tumors, where it has demonstrated a significant improvement in survival rates (disease-free as well as overall survival) in early stage and metastatic disease settings (217)