Contraindications for GLP-1 receptor agonists are pancreatitis, family history of medullary thyroid cancer, pancreas or kidney dysfunction, and diabetic retinopathy
Oxidative damage is the earliest event in Alzheimer disease
The challenge is that the enthusiasm for peptides has outpaced information and education
Indeed, studies on the use of GLP-1Ra mostly included patients with diabetes who were administered a dose used in this condition, did not have adequate bone parameters as primary endpoints, and had short follow-up periods
That is nearly 30 pounds for a 200-pound starting weight, achieved over roughly 15 months
GLP-1 agonists have demonstrated anti-inflammatory effects in the central nervous system, potentially breaking this feedback loop